Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
作者： R. L. Yauch , G. J. P. Dijkgraaf , B. Alicke , T. Januario , C. P. Ahn
关键词:
摘要: The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a drug that inhibits Hh …
sciencemag.org
harvard.edu
elsevier.com参考文章(16)
Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh, Anne Ryan, Qimin Gu, Chaohui Zhang, Jeannette M. Bonifas, Ching-Wan Lam, Mary Hynes, Audrey Goddard, Arnon Rosenthal, Ervin H Epstein, Frederic J. de Sauvage, Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. ,vol. 391, pp. 90- 92 ,(1998) , 10.1038/34201
Glen J. Weiss, Mitesh J. Borad, Christine L. Hann, Julie R. Brahmer, Howard M. Mackey, Bertram L. Lum, Walter C. Darbonne, James C. Marsters, Frederic J. de Sauvage, Jennifer A. Low, Daniel D. Von Hoff, Patricia M. LoRusso, Charles M. Rudin, Josina C. Reddy, Robert L. Yauch, Raoul Tibes, Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma New England Journal of Medicine. ,vol. 361, pp. 1164- 1172 ,(2009) , 10.1056/NEJMOA0905360
Lisa V. Goodrich, Ljiljana Milenković, Kay M. Higgins, Matthew P. Scott, Altered Neural Cell Fates and Medulloblastoma in MousepatchedMutants Science. ,vol. 277, pp. 1109- 1113 ,(1997) , 10.1126/SCIENCE.277.5329.1109
Daniel M. Rosenbaum, Søren G. F. Rasmussen, Brian K. Kobilka, The structure and function of G-protein-coupled receptors Nature. ,vol. 459, pp. 356- 363 ,(2009) , 10.1038/NATURE08144
Robert T. Dorsam, J. Silvio Gutkind, G-protein-coupled receptors and cancer. Nature Reviews Cancer. ,vol. 7, pp. 79- 94 ,(2007) , 10.1038/NRC2069
Cyril Goudet, Virginie Binet, Laurent Prezeau, Jean-Philippe Pin, Allosteric modulators of class-C G-protein-coupled receptors open new possibilities for therapeutic application Drug Discovery Today: Therapeutic Strategies. ,vol. 1, pp. 125- 133 ,(2004) , 10.1016/J.DDSTR.2004.08.017
Andrej Šali, Tom L. Blundell, Comparative Protein Modelling by Satisfaction of Spatial Restraints Journal of Molecular Biology. ,vol. 234, pp. 779- 815 ,(1993) , 10.1006/JMBI.1993.1626
William R Polkinghorn, Nancy J Tarbell, Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification. Nature Reviews Clinical Oncology. ,vol. 4, pp. 295- 304 ,(2007) , 10.1038/NCPONC0794
Justyna T. Romer, Hiromichi Kimura, Susan Magdaleno, Ken Sasai, Christine Fuller, Helen Baines, Michele Connelly, Clinton F. Stewart, Stephen Gould, Lee L. Rubin, Tom Curran, Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice Cancer Cell. ,vol. 6, pp. 229- 240 ,(2004) , 10.1016/J.CCR.2004.08.019
Lee L. Rubin, Frederic J. de Sauvage, Targeting the Hedgehog pathway in cancer Nature Reviews Drug Discovery. ,vol. 5, pp. 1026- 1033 ,(2006) , 10.1038/NRD2086