Cancer Stem Cells: An Innovative Therapeutic Approach

摘要: Cancer stem cells (CSCs) are gaining prominence in oncology. The characterization of the molecular phenotype CSCs or “cancer cell-like cells” can clarify several intriguing and obscure aspects cancer pathophysiology (e.g., cell dormancy, chemoresistance, metastasis) could represent a fundamental advance terms early diagnosis selective therapy for cancer. Moreover, understanding underlying pathogenetic mechanisms expand therapeutic applications normal adult by reducing risk disordered uncontrolled potentially tumorigenic differentiation. An explosion emerging diagnostic options treatment that selectively target has occurred recent years. These include targeting surface proteins, various activated signaling pathways, different molecules niche, drug resistance mechanisms. Importantly, approaching research investigating pathogenesis these is increasing knowledge disease, emphasizing certain concepts have been partially neglected facilitating global vision complex biology.