HDAC Inhibitors and Cancer Therapy

摘要: Maintenance of normal cell growth and differentiation is highly dependent on coordinated tight transcriptional regulation genes. In cancer, genes encoding regulators are abnormally expressed. Particularly, silencing tumor suppressor under the control chromatin modifications a major underlying cause unregulated cellular proliferation transformation. Thus mechanisms, which regulate structure gene expression, have become attractive targets for anticancer therapy. Histone deacetylases enzymes that modify contribute to aberrant expression in cancer. Research over past decade has led development histone deacetylase inhibitors as agents. addition their effect epigenetic HDAC also acetylation state large number proteins involved oncogenic processes, resulting antitumor effects. The current monograph will review role protumorigenic mechanisms developmental status prospects cancer