Epigenetic Regulation of microRNA Expression: Targeting the Triple-Negative Breast Cancer Phenotype
作者： Bridgette M. Collins-Burow
DOI: 10.21236/ADA542496
关键词:
摘要: Abstract : The primary long-term objective of this research is to identify HDAC inhibitor (HDACi) regulated microRNAs which regulate the epithelial-to-mesenchymal transition (EMT) in triple-negative breast cancer (TNBC). Thus far we have assessed microRNA expression profiles two TNBC cell lines following treatment with HDACi identifying a number up- and down-regulated microRNAs. overall profile after was indicative less aggressive phenotype. Treatment also resulted increased E-cadherin as well decreased migration indicating reversal EMT These results, along our ongoing research, suggest ability reverse phenotype, associated metastatic disease, support future evaluation therapeutic options for clinical TNBC.
sci-hub.st 参考文章(63)
Victor Ambros, microRNAs: Tiny Regulators with Great Potential Cell. ,vol. 107, pp. 823- 826 ,(2001) , 10.1016/S0092-8674(01)00616-X
Peter W. Atadja, HDAC Inhibitors and Cancer Therapy Epigenetics and Disease. ,vol. 67, pp. 175- 195 ,(2011) , 10.1007/978-3-7643-8989-5_9
Sharmila Shankar, Rakesh K Srivastava, None, Histone Deacetylase Inhibitors: Mechanisms and Clinical Significance in Cancer: HDAC Inhibitor-Induced Apoptosis Advances in Experimental Medicine and Biology. ,vol. 615, pp. 261- 298 ,(2008) , 10.1007/978-1-4020-6554-5_13
Tyler J. Curiel, Matthew E. Burow, Christine M. Dugan, Jawed Alam, Barbara S. Beckman, Christopher B. Weldon, John L. Clayton, Daniel E. Frigo, Amanda P. Parker, Nancy N. Butler, Bernard M. Jaffe, Daniel Patten, Erin L. Coakley, Yan Tang, Steven Elliott, Sensitization of apoptotically-resistant breast carcinoma cells to TNF and TRAIL by inhibition of p38 mitogen-activated protein kinase signaling. International Journal of Oncology. ,vol. 24, pp. 1473- 1480 ,(2004) , 10.3892/IJO.24.6.1473
Mary Morrogh, Victor P Andrade, Dilip Giri, Rita A Sakr, Wooyul Paik, Li Xuan Qin, Crispinita D Arroyo, Edi Brogi, Monica Morrow, Tari A King, None, Cadherin-catenin complex dissociation in lobular neoplasia of the breast. Breast Cancer Research and Treatment. ,vol. 132, pp. 641- 652 ,(2012) , 10.1007/S10549-011-1860-0
Sohail F. Tavazoie, Claudio Alarcón, Thordur Oskarsson, David Padua, Qiongqing Wang, Paula D. Bos, William L. Gerald, Joan Massagué, Endogenous human microRNAs that suppress breast cancer metastasis Nature. ,vol. 451, pp. 147- 152 ,(2008) , 10.1038/NATURE06487
M. Garcia, D. Derocq, G. Freiss, H. Rochefort, Activation of estrogen receptor transfected into a receptor-negative breast cancer cell line decreases the metastatic and invasive potential of the cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 11538- 11542 ,(1992) , 10.1073/PNAS.89.23.11538
Soeren Torge Mees, Wolf Arif Mardin, Sonja Sielker, Edith Willscher, Norbert Senninger, Christina Schleicher, Mario Colombo-Benkmann, Joerg Haier, Involvement of CD40 Targeting miR-224 and miR-486 on the Progression of Pancreatic Ductal Adenocarcinomas Annals of Surgical Oncology. ,vol. 16, pp. 2339- 2350 ,(2009) , 10.1245/S10434-009-0531-4
P N Munster, K T Thurn, S Thomas, P Raha, M Lacevic, A Miller, M Melisko, R Ismail-Khan, H Rugo, M Moasser, S E Minton, A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer British Journal of Cancer. ,vol. 104, pp. 1828- 1835 ,(2011) , 10.1038/BJC.2011.156
Y Saito, H Suzuki, H Tsugawa, I Nakagawa, J Matsuzaki, Y Kanai, T Hibi, Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells Oncogene. ,vol. 28, pp. 2738- 2744 ,(2009) , 10.1038/ONC.2009.140