Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.
作者： X. Huang , J. Liu , T. Ketova , J. T. Fleming , V. K. Grover
关键词: Cerebral cortex 、 Anatomy 、 Sonic hedgehog 、 Cell biology 、 Transventricular 、 Radial glial cell 、 GABAergic 、 Neural development 、 Rhombic lip 、 Cerebellum 、 Biology
摘要: Cerebellar neurons are generated from two germinal neuroepithelia: the ventricular zone (VZ) and rhombic lip. Signaling mechanisms that maintain proliferative capacity of VZ resident progenitors remain elusive. We reveal Sonic hedgehog (Shh) signaling is active in cerebellar essential to radial glial cell proliferation expansion GABAergic interneurons. demonstrate cerebellum not source Shh signals early VZ, suggest a transventricular path for ligand delivery. In agreement, we detected presence protein circulating embryonic cerebrospinal fluid. This study identifies as an signal zone, underscoring potential contribution pathogenesis diseases associated with deregulated signaling, reveals regulating neural development.
jstor.org 
sci-hub.se 参考文章(39)
Nicolas F. Berbari, Amber K. O'Connor, Courtney J. Haycraft, Bradley K. Yoder, The primary cilium as a complex signaling center. Current Biology. ,vol. 19, ,(2009) , 10.1016/J.CUB.2009.05.025
Marion Wassef, Piercesare Grimaldi, Carlos Parras, François Guillemot, Ferdinando Rossi, Origins and control of the differentiation of inhibitory interneurons and glia in the cerebellum. Developmental Biology. ,vol. 328, pp. 422- 433 ,(2009) , 10.1016/J.YDBIO.2009.02.008
Tamara Caspary, Christine E. Larkins, Kathryn V. Anderson, The graded response to Sonic Hedgehog depends on cilia architecture. Developmental Cell. ,vol. 12, pp. 767- 778 ,(2007) , 10.1016/J.DEVCEL.2007.03.004
M E Hatten, Richard Wingate, The role of the rhombic lip in avian cerebellum development. Development. ,vol. 126, pp. 4395- 4404 ,(1999) , 10.1242/DEV.126.20.4395
Joseph Altman, None, Development of the Cerebellar System Relation to its Evolution, Structure, and Functions. ,(1997)
Joseph Altman, Shirley A. Bayer, Development of the Cerebellar System: In Relation to Its Evolution, Structure, and Functions ,(1996)
Corey Raffel, Benjamin Alderete, Deanne Hebrink, C. David James, Robert B. Jenkins, Daniel W. Fults, Lori Frederick, Sporadic Medulloblastomas Contain PTCH Mutations Cancer Research. ,vol. 57, pp. 842- 845 ,(1997)
Zoran B. Redzic, Jane E. Preston, John A. Duncan, Adam Chodobski, Joanna Szmydynger‐Chodobska, The choroid plexus-cerebrospinal fluid system: from development to aging. Current Topics in Developmental Biology. ,vol. 71, pp. 1- 52 ,(2005) , 10.1016/S0070-2153(05)71001-2
Marta Pascual, Ibane Abasolo, Ana Mingorance-Le Meur, Albert Martínez, José A Del Rio, Christopher VE Wright, Francisco X Real, Eduardo Soriano, None, Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 5193- 5198 ,(2007) , 10.1073/PNAS.0605699104
Paola Zordan, Laura Croci, Richard Hawkes, G. Giacomo Consalez, Comparative analysis of proneural gene expression in the embryonic cerebellum Developmental Dynamics. ,vol. 237, pp. 1726- 1735 ,(2008) , 10.1002/DVDY.21571