Children Are Not Small Adults: Importance of Molecular Analysis for Diagnosis, Prognosis, and Treatment of Pediatric CNS Tumors
作者： Peter Pytel
DOI: 10.1007/978-1-62703-116-5_6
关键词: Medulloblastoma 、 Medicine 、 Embryonal tumors 、 Pediatrics 、 Germ cell tumors 、 Astrocytoma 、 Molecular analysis 、 Pediatric CNS 、 Absolute number 、 Solid Neoplasm
摘要: CNS tumors account for 20–24 % of all pediatric neoplasms, making brain the most common type solid neoplasm in children and leading cause cancer-related deaths under age 14 years (Pediatrics 5:263–270, 2010). In overall frequency among are second only to leukemias, which 30 cases. Overall there about 3,400 new cases a year within USA (Curr Opin Pediatr 19:670–674, 2007). The biggest groups include gliomas (65 %), medulloblastomas other embryonal (26 craniopharyngiomas (4 %) (J Child Neurol 24:1375–1386, 2009). There may be some variation specific different geographic areas. Japan Taiwan, example, germ cell more while rarer (Child’s Nerv Syst 26:1029–1034, absolute number presenting with particular tumor is small because large diversity
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