Pediatric brain tumors: genetics and clinical outcome.
作者： Claudia Faria , José Miguéns , João Lobo Antunes , Duarte Salgado , Sofia Nunes
DOI: 10.3171/2009.10.PEDS09240
关键词: Medicine 、 Primary Brain Tumors 、 Comparative genomic hybridization 、 El Niño 、 Pathology 、 Intracranial tumor 、 GBM - Glioblastoma multiforme 、 Genetics 、 Pediatric brain 、 Central nervous system disease 、 Desmoplastic medulloblastoma
摘要: Object In this paper the authors' goal was to investigate genetic characteristics of primary brain tumors in children and determine their influence on clinical outcome. Methods The authors performed high-resolution comparative genomic hybridization studies 14 low-grade 12 high-grade neoplasms 26 who underwent surgery between 2005 2007. Results Complex alterations were observed 2 (14.3%) lowgrade lesions 8 (66.6%) lesions. High-level amplifications DNA detected 3 cases, namely a desmoplastic medulloblastoma where c-Myc amplification found. Gains 1q 6 that classified as ependymomas, astrocytomas, oligodendrogliomas, oligoastrocytomas, gangliogliomas. When correlated genetics with outcome, they noted among only patients presented complex hybridi...
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