Bad wrap: Myelin and myelin plasticity in health and disease.

摘要: Human central nervous system myelin development extends well into the fourth decade of life, and this protracted period underscores potential for experience to modulate myelination. The concept plasticity implies adaptability in structure function response experiences during beyond. Mounting evidence supports neuronal activity-regulated changes myelin-forming cells, including oligodendrocyte precursor cell proliferation, oligodendrogenesis modulation microstructure. In healthy individuals, associative white matter structures brain is implicated learning motor both rodents humans. Activity-dependent cells may influence neural networks that depend on convergence numerous signals a temporal spatial scale. However, dysregulation can disadvantageously alter microstructure result aberrant circuit or contribute pathological proliferation. Emerging roles normal neurological disease are discussed. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 123-135, 2018.