The emerging functions of oligodendrocytes in regulating neuronal network behaviour

摘要: Myelin is required for efficient nerve conduction, but not all axons are myelinated to the same extent. Here we review recent studies that have revealed distinct myelination patterns of different axonal paths, suggesting an or none phenomenon and its presence finely regulated in central nervous system networks. Whereas powerful reductionist biology has led important knowledge how oligodendrocytes function by themselves, little known about their role neuronal We still do understand integrate information from neurons adapt need system. An intricate cross talk between glia likely exist determine circuits operate as a whole. Dissecting these mechanisms using integrative systems approaches one major challenges ahead.