Stem cells in brain tumor development.
作者： Sheila R. Alcantara Llaguno , Yuntao Chen , Renée M. McKay , Luis F. Parada
DOI: 10.1016/B978-0-12-380916-2.00002-4
关键词:
摘要: Gliomas are highly infiltrative and aggressive brain tumors that resistant to conventional therapies. Recent studies have implicated neural stem cells (NSCs) in tumor initiation development. Subpopulations of stem-like cancer also been isolated from tumors, purported be important mediators malignant behavior therapeutic resistance. Similar signaling pathways may operative both cells, suggesting developmental systems provide clues on tumorigenesis. Transcriptional regulators such as microRNAs contribute NSC Understanding the biology their regulatory mechanisms directly impact current efforts for more directed therapeutics against these tumors.
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