Molecular pathways and potential therapeutic targets in glioblastoma multiforme

摘要: Glioblastoma multiforme (GBM) is the most common primary brain malignancy. The current standard of therapy consists surgical resection followed by concurrent chemoradiotherapy with temozolomide. Despite steady advances in all therapeutic modalities, clinical improvements have been slow and prognosis remains poor. Utilizing powerful large-scale molecular techniques, several key pathways implicated gliomagenesis recently identified confirmed. These represent potential targets, developing novel methods to specifically manipulate these pathways, we may achieve a meaningful substantial improvement way treat GBM. Here, present discuss status research into targets