A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.
作者： R. Nishikawa , X. D. Ji , R. C. Harmon , C. S. Lazar , G. N. Gill
关键词: Tumor progression 、 Molecular biology 、 Receptor 、 Mutation 、 Cell growth 、 Biology 、 Mutant 、 ERBB3 、 Epidermal growth factor receptor 、 Blot
摘要: … amplification of the epidermal growth factor receptor (EGFR) gene. This episomal amplification occurs in 40-50% of glioblastomas, which also normally express endogenous receptors. …
harvard.edu
core.ac.uk
sci-hub.se 参考文章(47)
Michael Antczak, Hsing Jien Kung, Tom Flickinger, Maribeth Raines, Thomas Callaghan, Mike Myers, A complete description of the EGF-receptor exon structure: implication in oncogenic activation and domain evolution. Oncogene. ,vol. 8, pp. 2939- 2948 ,(1993)
D.L. Cadena, C.L. Chan, G.N. Gill, The intracellular tyrosine kinase domain of the epidermal growth factor receptor undergoes a conformational change upon autophosphorylation. Journal of Biological Chemistry. ,vol. 269, pp. 260- 265 ,(1994) , 10.1016/S0021-9258(17)42343-X
U. Novak, A. W. Burgess, A. H. Kaye, L. T. Malden, Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme. Cancer Research. ,vol. 48, pp. 2711- 2714 ,(1988)
G N Gill, T Kawamoto, C Cochet, A Le, J D Sato, H Masui, C McLeod, J Mendelsohn, Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. Journal of Biological Chemistry. ,vol. 259, pp. 7755- 7760 ,(1984) , 10.1016/S0021-9258(17)42857-2
M. Nordenskjold, E. Carlbom, V. P. Collins, W. K. Cavenee, C. D. James, J. He, J. He, Chromosome 9 deletion mapping reveals interferon alpha and interferon beta-1 gene deletions in human glial tumors. Cancer Research. ,vol. 51, pp. 1684- 1688 ,(1991)
G Carpenter, S Cohen, Epidermal growth factor. Journal of Biological Chemistry. ,vol. 265, pp. 7709- 7712 ,(1972) , 10.1016/S0021-9258(19)38983-5
Richard M. Cawthon, Carolyn A. Pedone, Douglas Brockmeyer, Dan Fults, Micam W. Tullous, p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression. Cancer Research. ,vol. 52, pp. 674- 679 ,(1992)
Masakazu Ueda, Nobuyoshi Shimizu, Nobuyoshi Shimizu, Osahiko Abe, John Hunts, Soji Ozawa, Ira Pastan, HYPERPRODUCTION AND GENE AMPLIFICATION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR IN SQUAMOUS CELL CARCINOMAS Japanese Journal of Cancer Research. ,vol. 76, pp. 663- 666 ,(1985) , 10.20772/CANCERSCI1985.76.8_663
P. Nowell, The clonal evolution of tumor cell populations Science. ,vol. 194, pp. 23- 28 ,(1976) , 10.1126/SCIENCE.959840
E Jaros, RH Perry, L Adam, PJ Kelly, PJ Crawford, RM Kalbag, AD Mendelow, RP Sengupta, ADJ Pearson, Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours. British Journal of Cancer. ,vol. 66, pp. 373- 385 ,(1992) , 10.1038/BJC.1992.273