Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme.
作者： U. Novak , A. W. Burgess , A. H. Kaye , L. T. Malden
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摘要: Abstract Primary brain tumors of glial origin often overexpress epidermal growth factor receptors (EGF-Rs). This may be associated with amplification the EGF-R gene. We have examined tissue from 23 glioblastoma multiforme and found rearrangement gene in four these. The cytoplasmic domain was invariably amplified these tumors, while binding not uniformly three tumors. Western blot analysis protein revealed high levels a truncated two amplification.
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