Amplification of DNA sequences in mammalian cells.
作者： Joyce L. Hamlin , Tzeng-Horng Leu , James P. Vaughn , Chi Ma , Pieter A. Dijkwel
DOI: 10.1016/S0079-6603(08)60010-0
关键词:
摘要: Publisher Summary This chapter discusses the aberrant DNA sequence amplification processes that occur in mammalian cells because of clinical relevance to drug resistance and oncogene tumors underlying mechanisms seem close being understood at molecular level. What seemed be a relatively esoteric mutational phenomenon is now major determining factor genesis cancer, as well serious deterrent successful chemotherapeutic treatment regimens. The traces history discovery amplification, cites several examples, similarities differences among these systems. Important methodologies developed for studying amplified sequences are also presented chapter. It reviews viable models attempt explain shows way resolution promises teach much about both normal chromosome dynamics (e. g., replication, recombination repair processes, chromosomal breakage healing).
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