MECHANISMS LEADING TO CHROMOSOMAL INSTABILITY IN ORAL CANCER CELLS

摘要: In the United States, cancer is a leading cause of death, second only to heart disease (MOKDAD et al. 2004). Although it estimated that in 2005, oral cavity will account for 2.1% cases and 1.3% overall deaths U. S. (JEMAL 2005), high-risk behaviors such as smoking cigarettes, using smokeless tobacco, consuming excessive alcohol have been shown play major role OSCC development. Exposure environmental agents, including tobacco products, alcoholic beverages, and/or viruses, human papillomavirus (FORASTIERE 2001; HO CALIFANO 2004; MORK 2001) profound influence on cells within cavity. These factors induce genetic alterations chromosomal alterations, DNA changes, epigenetic changes methylation affect regulation. Genetic are useful biological markers assist early detection response therapy (SIDRANSKY 1995). Currently, however, there no biomarkers identify involved One alteration observed 45% amplification band, 11q13. This event has follow dysplastic cellular but occur prior development carcinoma situ 2001). Therefore, 11q13 may be biomarker detecting OSCC. addition, understanding molecular mechanisms promote gene provide valuable information devising novel prevention measures therapies. current study, we show primary mechanism promoting BFB cycles. Furthermore, suggest breakage at common fragile site, FRA11F, responsible initiating amplification. By determining leads OSCC, additional investigations focusing basis this process important developing successful treatments increase survival rate individuals afflicted with cancer.