EGF Family Receptors and Their Ligands in Human Cancer
作者： Careen K. Tang , Marc E. Lippman
DOI: 10.1016/B978-012312411-1/50006-8
关键词:
摘要: Publisher Summary Amplification or overexpression of epidermal growth factor (EGF) family receptors is frequently implicated in human cancer. This chapter helps understanding the involvement EGF and their ligands neoplasia. The EGF-related peptides can be divided into two groups, depending on binding specificities. One group binds predominantly to receptor (EGFR) while second peptides, product a single gene, composed variously named neu differentiation factors bind directly ErbB-4 with high affinity. are also potentially useful targets for anticancer therapy. Abnormalities EGFR-signaling pathway have been associated development many cancers. EGFR therefore used as potential target chemoprevention. Over expression ErbB-2 has detected adenocarcinomas from several tissues including 30% lung stomach adenocarcinomas. amplification correlated poor prognosis breast Immunotherapy long considered promising approach treatment Monoclonal antibodies raised against both system extracellular domain ErbB-2.
sci-hub.st 参考文章(347)
Daisuke Kohda, Fuyuhiko Inagaki, Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions. Biochemistry. ,vol. 31, pp. 11928- 11939 ,(1994) , 10.1021/BI00162A036
N. R. JONES, M. L. ROSSI, M. GREGORIOU, J. T. HUGHES, Investigation of the expression of epidermal growth factor receptor and blood group A antigen in 110 human gliomas. Neuropathology and Applied Neurobiology. ,vol. 16, pp. 185- 192 ,(1990) , 10.1111/J.1365-2990.1990.TB01155.X
Jeffrey Schlom, Basic principles and applications of monoclonal antibodies in the management of carcinomas: the Richard and Hinda Rosenthal Foundation award lecture. Cancer Research. ,vol. 46, pp. 3225- 3238 ,(1986)
K. Nagata, D. Kohda, H. Hatanaka, S. Ichikawa, S. Matsuda, T. Yamamoto, A. Suzuki, F. Inagaki, Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4. The EMBO Journal. ,vol. 13, pp. 3517- 3523 ,(1994) , 10.1002/J.1460-2075.1994.TB06658.X
S P Soltoff, K L Carraway, S A Prigent, W G Gullick, L C Cantley, ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Molecular and Cellular Biology. ,vol. 14, pp. 3550- 3558 ,(1994) , 10.1128/MCB.14.6.3550
Joyce Taylor-Papadimitriou, Report on the first international workshop on carcinoma-associated mucins. International Journal of Cancer. ,vol. 49, pp. 1- 5 ,(1991) , 10.1002/IJC.2910490102
R. M. Elledge, G. M. Clark, G. C. Chamness, C. K. Osborne, Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United States. Journal of the National Cancer Institute. ,vol. 86, pp. 705- 712 ,(1994) , 10.1093/JNCI/86.9.705
B.A. Gusterson, L.G. Machin, W.J. Gullick, N.M. Gibbs, T.J. Powles, P. Price, A. McKinna, S. Harrison, Immunohistochemical distribution of c-erbB-2 in infiltrating and in situ breast cancer. International Journal of Cancer. ,vol. 42, pp. 842- 845 ,(1988) , 10.1002/IJC.2910420608
Masaharu Seno, Hiroko Tada, Megumi Kosaka, Reiko Sasada, Koichi Igarashi, Yuen Shing, Judah Folkman, Masakazu Ueda, Hidenori Yamada, Human Betacellulin, a Member of the EGF Family Dominantly Expressed in Pancreas and Small Intestine, is Fully Active in a Monomeric Form Growth Factors Journal. ,vol. 13, pp. 181- 191 ,(1996) , 10.3109/08977199609003220
D F Stern, P A Heffernan, R A Weinberg, p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity. Molecular and Cellular Biology. ,vol. 6, pp. 1729- 1740 ,(1986) , 10.1128/MCB.6.5.1729