Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
作者： Hyun-Soo Cho , Karen Mason , Kasra X. Ramyar , Ann Marie Stanley , Sandra B. Gabelli
DOI: 10.1038/NATURE01392
关键词: ERBB4 、 Cancer research 、 Epidermal growth factor receptor 、 ErbB 、 Trastuzumab 、 Receptor tyrosine kinase 、 Receptor 、 ERBB3 、 Molecular biology 、 ErbB Receptors 、 Biology
摘要: … extracellular regions of rat HER2 at 2.4 Å and human HER2 complexed with the Herceptin … conformation for HER2 that resembles a ligand-activated state, and show HER2 poised to …
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