Identification of human brain tumour initiating cells
作者： Sheila K. Singh , Cynthia Hawkins , Ian D. Clarke , Jeremy A. Squire , Jane Bayani
DOI: 10.1038/NATURE03128
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摘要: The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with stem cell properties,. Although the existence of CSCs in human leukaemia is established,, little evidence exists for CSCs in solid tumours, except for breast cancer. Recently, we prospectively isolated a CD133+ cell subpopulation from human brain tumours that exhibited stem cell properties in vitro. However, the true measures of CSCs are their capacity for self renewal and exact recapitulation of the original …
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