Cancer Stem Cells and Disease Prognosis
作者： Zeshaan A. Rasheed , Jeanne Kowalski , William H. Matsui
DOI: 10.1007/978-1-61779-246-5_19
关键词: Multiple myeloma 、 Clinical trial 、 Cancer 、 Internal medicine 、 Tumor formation 、 Cancer stem cell 、 Disease 、 Oncology 、 Disease prognosis 、 Clinical significance 、 Medicine
摘要: Cancer stem cells (CSCs) represent distinct tumor defined by their capacity for formation, self-renewal, and differentiation. In addition, the CSC hypothesis has been extended to suggest that specific cell populations are also responsible clinical scenarios such as initial disease relapse following therapy, cancer progression including transformation of indolent aggressive in hematologic malignancies development metastatic solid tumors. However, several questions regarding CSCs remain subject intense debate, actual relevance and/or whether eradication will actually improve patient outcomes. this chapter, we review strategies identify evidence they play a role prognosis, progression, therapeutic resistance; well discuss potential barriers designing interpreting trials studying targeting therapies.
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