Loss of imprinting of IGF2 and the epigenetic progenitor model of cancer.
作者： Jaclyn L Congress , Erwin C Wang , Christopher J Shoff , Mark B Leick , G Ian Gallicano
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摘要: Among the hypotheses discussing cancer formation, stem cell (CSC) theory is one receiving widespread support. One version of this states that changes in otherwise healthy cells can cause formation tumor- initiating (TICs), which have potential to create precancerous lead CSC formation. These CSCs be rare, contrast their differentiated progeny, give rise vast majority tumor mass most cancers. Loss imprinting (LOI) insulin-like growth factor-2 (IGF2) gene change produce these TICs via an epigenetic progenitor model tumorigenesis. While IGF2 usually supports normal cellular growth, LOI may overexpression and moreover global chromatin instability. This modification has been observed many forms cancer, given effect its role detecting a loss could serve as valuable diagnostic tool. Preclinical data shown some progress identifying therapeutic approaches seeking exploit relationship. Thus, further research surrounding increased understanding several types enhance therapies against diseases.
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