WOMEN IN CANCER THEMATIC REVIEW: Diverse functions of DNA methylation: implications for prostate cancer and beyond
作者： Thomas J Sweet , Angela H Ting
DOI: 10.1530/ERC-16-0306
关键词:
摘要: Prostate cancer is one of the most common malignancies in men worldwide. Current clinical screening ensures that prostate cancers are diagnosed while still organ confined, but disease outcome highly variable. Thus, a better understanding molecular features contributing to aggressiveness being sought. For many cancers, aberrant genome-wide patterns cytosine DNA methylation CpG dinucleotides distinguish tumor from normal tissue and contribute progression by altering transcriptome. In cancer, recent genomic studies identified high grade-specific differential gene promoters, bodies, 3' ends at distal regulatory elements. Using examples developmental systems, we will discuss how each these contexts can transcriptome diversity modulating transcription initiation, alternative start site selection, pre-mRNA splicing polyadenylation. Alternative transcripts same often exhibit altered protein-coding potential, translatability, stability and/or localization. All have functional consequences cells. future work, it be important determine if abnormalities modify through some or all mechanisms methylation-mediated alterations impact tumorigenesis aggressiveness.
bioscientifica.com
sci-hub.se 参考文章(86)
Jaclyn L Congress, Erwin C Wang, Christopher J Shoff, Mark B Leick, G Ian Gallicano, Loss of imprinting of IGF2 and the epigenetic progenitor model of cancer. Journal of stem cells. ,vol. 1, pp. 59- 74 ,(2012)
Masaki Okano, Shaoping Xie, En Li, Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases Nature Genetics. ,vol. 19, pp. 219- 220 ,(1998) , 10.1038/890
Dan Robinson, Eliezer M Van Allen, Yi-Mi Wu, Nikolaus Schultz, Robert J Lonigro, Juan-Miguel Mosquera, Bruce Montgomery, Mary-Ellen Taplin, Colin C Pritchard, Gerhardt Attard, Himisha Beltran, Wassim Abida, Robert K Bradley, Jake Vinson, Xuhong Cao, Pankaj Vats, Lakshmi P Kunju, Maha Hussain, Felix Y Feng, Scott A Tomlins, Kathleen A Cooney, David C Smith, Christine Brennan, Javed Siddiqui, Rohit Mehra, Yu Chen, Dana E Rathkopf, Michael J Morris, Stephen B Solomon, Jeremy C Durack, Victor E Reuter, Anuradha Gopalan, Jianjiong Gao, Massimo Loda, Rosina T Lis, Michaela Bowden, Stephen P Balk, Glenn Gaviola, Carrie Sougnez, Manaswi Gupta, Y Yu Evan, Elahe A Mostaghel, Heather H Cheng, Hyojeong Mulcahy, Lawrence D True, Stephen R Plymate, Heidi Dvinge, Roberta Ferraldeschi, Penny Flohr, Susana Miranda, Zafeiris Zafeiriou, Nina Tunariu, Joaquin Mateo, Raquel Perez-Lopez, Francesca Demichelis, Brian D Robinson, Marc Schiffman, David M Nanus, Scott T Tagawa, Alexandros Sigaras, Kenneth W Eng, Olivier Elemento, Andrea Sboner, Elisabeth I Heath, Howard I Scher, Kenneth J Pienta, Philip Kantoff, Johann S De Bono, Mark A Rubin, Peter S Nelson, Levi A Garraway, Charles L Sawyers, Arul M Chinnaiyan, None, Integrative clinical genomics of advanced prostate cancer Cell. ,vol. 161, pp. 1215- 1228 ,(2015) , 10.1016/J.CELL.2015.05.001
Matahi Moarii, Valentina Boeva, Jean-Philippe Vert, Fabien Reyal, Changes in correlation between promoter methylation and gene expression in cancer. BMC Genomics. ,vol. 16, pp. 873- 873 ,(2015) , 10.1186/S12864-015-1994-2
Nelma Pertega-Gomes, Jose R. Vizcaino, Sergio Felisbino, Anne Y. Warren, Greg Shaw, Jonathan Kay, Hayley Whitaker, Andy G. Lynch, Lee Fryer, David E. Neal, Charles E. Massie, Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer. Oncotarget. ,vol. 6, pp. 21675- 21684 ,(2015) , 10.18632/ONCOTARGET.4328
Adam Blattler, Lijing Yao, Heather Witt, Yu Guo, Charles M Nicolet, Benjamin P Berman, Peggy J Farnham, Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes Genome Biology. ,vol. 15, pp. 469- 469 ,(2014) , 10.1186/S13059-014-0469-0
Thomas A. Stamey, Biological determinants of cancer progression in men with prostate cancer. JAMA. ,vol. 281, pp. 1395- 1400 ,(1999) , 10.1001/JAMA.281.15.1395
Elizabeth M Blackwood, James T Kadonaga, Going the Distance: A Current View of Enhancer Action Science. ,vol. 281, pp. 60- 63 ,(1998) , 10.1126/SCIENCE.281.5373.60
Morgan L Maeder, James F Angstman, Marcy E Richardson, Samantha J Linder, Vincent M Cascio, Shengdar Q Tsai, Quan H Ho, Jeffry D Sander, Deepak Reyon, Bradley E Bernstein, Joseph F Costello, Miles F Wilkinson, J Keith Joung, Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins Nature Biotechnology. ,vol. 31, pp. 1137- 1142 ,(2013) , 10.1038/NBT.2726
F Valdés-Mora, S J Clark, Prostate cancer epigenetic biomarkers: next-generation technologies. Oncogene. ,vol. 34, pp. 1609- 1618 ,(2015) , 10.1038/ONC.2014.111