Curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway.
作者： Binqiang Tian , Yingmei Zhao , Tao Liang , Xuxiao Ye , Zuowei Li
DOI: 10.1080/1061186X.2017.1306535
关键词: Chemistry 、 AKT1 、 Cancer research 、 Phosphorylation 、 PI3K/AKT/mTOR pathway 、 P70-S6 Kinase 1 、 Carcinogenesis 、 RPTOR 、 Curcumin 、 Protein kinase B
摘要: … Thus, IGF2 is an important cancer drug target. In this study, we found that curcumin suppressed IGF2 expression at a transcriptional level, inhibited IGF2-mediated PI3K/AKT/m-TOR …
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