Gliomagenesis: genetic alterations and mouse models
作者： Eric C. Holland
DOI: 10.1038/35052535
关键词: Biology 、 Disease 、 Glioblastoma 、 Signal transduction 、 Cell cycle 、 Etiology 、 Bioinformatics 、 Treatment strategy
摘要: Glioblastoma multiforme is the most malignant of primary brain tumours and almost always fatal. The treatment strategies for this disease have not changed appreciably many years are based on a limited understanding biology disease. However, in past decade, characteristic genetic alterations been identified gliomas that might underlie initiation or progression Recent modelling experiments mice helping to delineate molecular aetiology providing systems identify test novel rational therapeutic strategies.
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