Biology and treatment of malignant glioma.

摘要: Malignant gliomas are a heterogeneous group of tumors that associated with significant morbidity and mortality. The development the malignant phenotype is result complex series events influence gene expression, angiogenesis, invasion favor growth tumor cells. Currently, management glioma consists symptom control cytoreduction combination surgery, radiation therapy, chemotherapy. However, there no satisfactory regimen available for adjuvant or salvage chemotherapy these neoplasms. An overview biologic mechanisms, grading systems, treatment options anaplastic astrocytoma glioblastoma multiforme presented.