Angiogenesis in Gliomas

摘要: Malignant brain tumors, including glioblastoma (GBM), display growth, survival, and invasive properties that are coupled to blood vessels vascular-derived factors. For example, GBM stem cells (GSCs) home perivascular niches tumor commonly disperse through the microenvironment via extracellular matrix (ECM)-rich vascular basement membranes. Anti-vascular agents target angiogenesis, particularly those involving endothelial cell growth factor-A (VEGF-A) its receptors, improve progression-free survival in patients. However, these benefits often transient due compensation by alternative angiogenic pathways. The detailed molecular mechanisms couple during progression as well following anti-angiogenesis therapies just beginning be elucidated, with various cytokines, factors, ECM proteins playing important roles. In this review we will highlight pathways link cerebral progression, invasion. We also discuss underlying GBM-induced a particular focus placed on roles for integrin adhesion receptors their protein ligands. Therapies angiogenesis other cancers summarized.