Phase II Trial of Murine 131I-Labeled Antitenascin Monoclonal Antibody 81C6 Administered Into Surgically Created Resection Cavities of Patients With Newly Diagnosed Malignant Gliomas
作者： David A Reardon , Gamal Akabani , R Edward Coleman , Allan H Friedman , Henry S Friedman
关键词: Anaplastic astrocytoma 、 Chemotherapy 、 Surgically-Created Resection Cavity 、 Pathology 、 Gastroenterology 、 Medicine 、 Survival rate 、 Glioma 、 Internal medicine 、 Central nervous system disease 、 Radiation therapy 、 Toxicity
摘要: PURPOSE: To assess the efficacy and toxicity of intraresection cavity 131I-labeled murine antitenascin monoclonal antibody 81C6 determine its true response rate among patients with newly diagnosed malignant glioma. PATIENTS AND METHODS: In this phase II trial, 120 mCi was injected directly into surgically created resection 33 previously untreated glioma (glioblastoma multiforme [GBM], n = 27; anaplastic astrocytoma, 4; oligodendroglioma, 2). Patients then received conventional external-beam radiotherapy followed by a year alkylator-based chemotherapy. RESULTS: Median survival for all those GBM 86.7 79.4 weeks, respectively. Eleven remain alive at median follow-up 93 weeks (range, 49 to 220 weeks). Nine (27%) developed reversible hematologic toxicity, histologically confirmed, treatment-related neurologic occurred in five (15%). One patient (3%) ...
jco.org参考文章(40)
K. Hopkins, C. Chandler, J. Bullimore, D. Sandeman, H. Coakham, J.T. Kemshead, A pilot study of the treatment of patients with recurrent malignant gliomas with intratumoral yttrium-90 radioimmunoconjugates Radiotherapy and Oncology. ,vol. 34, pp. 121- 131 ,(1995) , 10.1016/0167-8140(95)01514-H
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Joseph B. Ventimiglia, Carol J. Wikstrand, Lawrence E. Ostrowski, Mario A. Bourdon, Virginia A. Lightner, Darell D. Bigner, Tenascin expression in human glioma cell lines and normal tissues. Journal of Neuroimmunology. ,vol. 36, pp. 41- 55 ,(1992) , 10.1016/0165-5728(92)90029-K
Edward V. Colapinto, Yisheng Lee, Peter A. Humphrey, Michael R. Zalutsky, Henry S. Friedman, Dennis E. Bullard, Darell D. Bigner, The Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic Mice British Journal of Neurosurgery. ,vol. 2, pp. 179- 191 ,(1988) , 10.3109/02688698808992668
SHOJI KIDO, JUNPEI IKEZOE, HIROAKI NAITO, SHINICHI TAMURA, TAKAHIRO KOZUKA, WATARU ITO, KAZUO SHIMURA, HISATOYO KATO, Single-exposure dual-energy chest images with computed radiography. Evaluation with simulated pulmonary nodules. Investigative Radiology. ,vol. 28, pp. 482- 487 ,(1993) , 10.1097/00004424-199306000-00002
W. J. Curran, C. B. Scott, J. Horton, J. S. Nelson, A. S. Weinstein, A. J. Fischbach, C. H. Chang, M. Rotman, S. O. Asbell, R. E. Krisch, D. F. Nelson, Recursive Partitioning Analysis of Prognostic Factors in Three Radiation Therapy Oncology Group Malignant Glioma Trials Journal of the National Cancer Institute. ,vol. 85, pp. 704- 710 ,(1993) , 10.1093/JNCI/85.9.704
Dennis C. Shrieve, Eben Alexander, Patrick Y. Wen, Howard A. Fine, Hanne M. Kooy, Peter McL. Black, Jay S. Loeffler, Comparison of stereotactic radiosurgery and brachytherapy in the treatment of recurrent glioblastoma multiforme Neurosurgery. ,vol. 36, pp. 275- 284 ,(1995) , 10.1227/00006123-199502000-00006
J. S. Loeffler, E. Alexander, P. Y. Wen, W. M. Shea, C. N. Coleman, H. M. Kooy, H. A. Fine, L. A. Nedzi, B. Silver, N. E. Riese, P. McL. Black, Results of Stereotactic Brachytherapy Used in the Initial Management of Patients With Glioblastoma Journal of the National Cancer Institute. ,vol. 82, pp. 1918- 1921 ,(1990) , 10.1093/JNCI/82.24.1918
Gregory M.M Videtic, Laurie E Gaspar, L Zamorano, James Fontanesi, Kenneth J Levin, William J Kupsky, Samuel Tekyi-Mensah, Use of the RTOG recursive partitioning analysis to validate the benefit of iodine-125 implants in the primary treatment of malignant gliomas. International Journal of Radiation Oncology Biology Physics. ,vol. 45, pp. 687- 692 ,(1999) , 10.1016/S0360-3016(99)00244-8
Laurie E. Gaspar, Barbara J. Fisher, David R. Macdonald, Deborah V. Leber, Edward C. Halperin, S.Clifford Schold, J.Gregory Cairncross, Supratentorial malignant glioma: Patterns of recurrence and implications for external beam local treatment International Journal of Radiation Oncology*Biology*Physics. ,vol. 24, pp. 55- 57 ,(1992) , 10.1016/0360-3016(92)91021-E