摘要: Angiogenesis is a complex process regulated by multiple stimulatory and inhibitory factors that are able to modulate the migration and/or proliferation of microvascular cells with objective formation neovasculature from preexisting vessels. It involves well-coordinated steps including production release angiogenic factors, proteolytic degradation extracellular matrix components allow capillary sprout, directional cells, final composition new vessels [Senger (1996) Am. J. Pathol. 149:1-7]. present in number hypoxic ischemic conditions central nervous system, particular infarctions infectious processes. also plays an important role malignant primary tumors. Glioblastomas, most gliomas adults, among all human This review will examine recent data growth neoplastic reactive brain.
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