Recurrence of meningiomas.

摘要: BACKGROUND Macroscopic total resection with removal of involved dura and bone does not always prevent the recurrence meningioma histologically benign subtype. Many causative factors have been investigated, although mechanism remains unclear. Vascular endothelial growth factor (VEGF) is a key in meningiomas neovascularization, authors investigated whether VEGF expression can predict after macroscopic resection. METHODS Fifty-four patients supratentorial convexity were at least 3 years surgery or until tumor to clarify risk for recurrence. Patients restricted Simpson Grade 1 only, excluded multiple meningiomas, neurofibromatosis, atypical anaplastic meningiomas. Correlation between following statistically analyzed: age, gender, volume, shape, change, brain edema, vascular supply, histologic subtype, MIB-1 labeling index (LI), expression. RESULTS Of 54 meningioma, 34 positive (24: +1; 10: +2) VEGF, 20 negative. Six (11.1%) recurred during follow-up period. Multivariate analysis revealed that high levels constituted most useful predictor (P = 0.005), followed by LI 0.039). The other significant. recurrence, when it occurred, was within durally based. CONCLUSIONS The current results suggest are significantly related meningioma. secretion from microscopic residue remaining may induce which promotes Cancer 2000;89:1102–10. © 2000 American Society.