Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2

摘要: A hallmark of highly malignant human gliomas is their infiltration the brain. We analyzed a large number primary glioma biopsies and found high levels expression an angiogenic regulator, angiopoietin-2 (Ang2), in invasive areas, but not central regions, those tumors. In regions where Ang2 was overexpressed, increased matrix metalloprotease-2 (MMP-2) were also apparent. Consonant with these features, intracranial xenografts cells engineered to express into adjacent brain parenchyma compared isogenic control Ang2-expressing tumors that actively invading brain, MMP-2 angiogenesis evident. link between two features apparent, because stable by U87MG or treatment several cell lines recombinant vitro caused activation acquisition invasiveness. Conversely, MMP inhibitors suppressed Ang2-stimulated Ang2-induced invasion. These results suggest plays critical role inducing tumor infiltration, this phenotype MMP-2.