Glutamate Transporters: Expression and Function in Oligodendrocytes.

摘要: Glutamate, the main excitatory neurotransmitter of vertebrate central nervous system (CNS), is well known as a regulator neuronal plasticity and neurodevelopment. Such glutamate function thought to be mediated primarily by signaling through receptors. Thus, it requires tight regulation extracellular levels fine-tuned homeostasis that, when dysregulated, has been associated with wide range pathologies including neuropsychiatric, neurodevelopmental, neurodegenerative disorders. In mammalian CNS, are controlled family sodium-dependent transporters belonging solute carrier 1 (SLC1) that also referred amino acid (EAATs). The presumed EAATs best described in context synaptic transmission where expressed astrocytes neurons effectively regulate so synapses can independently. There is, however, increasing evidence cells other than neurons, they exhibit functions beyond clearance. this review, we will focus on expression myelinating oligodendrocytes. More specifically, discuss potential roles oligodendrocyte-expressed contributing homeostasis, regulating oligodendrocyte maturation CNS myelination exerting have traditionally addition, provide some examples for how dysregulation may involved pathophysiology neurologic diseases.