Primary structure and functional characterization of a high-affinity glutamate transporter
作者： Yoshikatsu Kanai , Matthias A. Hediger
DOI: 10.1038/360467A0
关键词:
摘要: GLUTAMATE transport across plasma membranes of neurons, glial cells and epithelial cells of the small intestine and kidney proceeds by high-and low-affinity transport systems1–5. High-affinity (Km 2–50 μM) transport systems have been described1, 6, 7 that are dependent on Na+ but not Cl− ions and have a preference for L-glutamate and D-and L-aspartate. In neurons high-affinity glutamate transporters are essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft6, 7. We …
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Arne Schousboe, Transport and Metabolism of Glutamate and Gaba in Neurons and Glial Cells International Review of Neurobiology. ,vol. 22, pp. 1- 45 ,(1981) , 10.1016/S0074-7742(08)60289-5
Y Deguchi, I Yamato, Y Anraku, Nucleotide sequence of gltS, the Na+/glutamate symport carrier gene of Escherichia coli B. Journal of Biological Chemistry. ,vol. 265, pp. 21704- 21708 ,(1990) , 10.1016/S0021-9258(18)45797-3
Hari Manev, Erminio Costa, Jarda T. Wroblewski, Alessandro Guidotti, Abusive stimulation of excitatory amino acid receptors: a strategy to limit neurotoxicity The FASEB Journal. ,vol. 4, pp. 2789- 2797 ,(1990) , 10.1096/FASEBJ.4.10.2165013
B Tolner, B Poolman, B Wallace, W N Konings, Revised Nucleotide Sequence of the gltP Gene, Which Encodes the Proton-Glutamate- Aspartate Transport Protein of Escherichia coli K-12 Journal of Bacteriology. ,vol. 174, pp. 2391- 2393 ,(1992) , 10.1128/JB.174.7.2391-2393.1992
H N Christensen, Role of amino acid transport and countertransport in nutrition and metabolism. Physiological Reviews. ,vol. 70, pp. 43- 77 ,(1990) , 10.1152/PHYSREV.1990.70.1.43
Jeffrey D. Rothstein, Lee J. Martin, Ralph W. Kuncl, Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis The New England Journal of Medicine. ,vol. 326, pp. 1464- 1468 ,(1992) , 10.1056/NEJM199205283262204
David Nicholls, David Attwell, The release and uptake of excitatory amino acids. Trends in Pharmacological Sciences. ,vol. 11, pp. 462- 468 ,(1990) , 10.1016/0165-6147(90)90129-V
Matthias A. Hediger, High resolution preparative gel electrophoresis of DNA fragments and plasmid DNA using a continuous elution apparatus. Analytical Biochemistry. ,vol. 159, pp. 280- 286 ,(1986) , 10.1016/0003-2697(86)90344-1
Tadeusz Pacholczyk, Randy D. Blakely, Susan G. Amara, Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. ,vol. 350, pp. 350- 354 ,(1991) , 10.1038/350350A0
Robert T. Fremeau, Marc G. Caron, Randy D. Blakely, Molecular cloning and expression of a high affinity l-proline transporter expressed in putative glutamatergic pathways of rat brain Neuron. ,vol. 8, pp. 915- 926 ,(1992) , 10.1016/0896-6273(92)90206-S