The neuroglial population in the primary visual cortex of the aging rhesus monkey.

摘要: The effects of age on neuroglial cells have been examined in the primary visual cortices rhesus monkeys that had behaviorally tested. assessment changes populations was made basis frequency occurrence profiles semithick sections osmicated tissue stained with toluidine blue. No were found numbers astrocytes and microglial age, but oligodendrocytes increased by about 50%. myelinated nerve bundles at level layer 4 also electron microscopy to assess fibers. fiber showing agerelated alterations their myelin sheaths increase age. There an age-related fibers sectioned through paranodes, indicating shorter lengths are being produced remyelination. These both correlate significantly oligodendrocyte profiles, suggesting additional required remyelinate whose broken down, probably death original parent oligodendroglial cell. Also most cognitively impaired greatest oligodendrocytes, this is a secondary correlation, reflecting fact altered slows down rate conduction along fibers, which leads cognitive decline. V C 2008 Wiley-Liss, Inc.