Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors
作者： Tarik Tihan , Mitchell S. Berger , Susan M. Chang , Michael D. Prados , Joseph Wiemels
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摘要: BACKGROUND The prediction of clinical behavior, response to therapy, and outcome infiltrative glioma is challenging. On the basis previous studies tumor biology, we defined five molecular groups with use three alterations: mutations in TERT promoter, IDH, codeletion chromosome arms 1p 19q (1p/19q codeletion). We tested hypothesis that within based on these features, tumors would have similar variables, acquired somatic alterations, germline variants. METHODS scored as negative or positive for each markers 1087 gliomas compared alterations patient characteristics among primary groups. Using 11,590 controls, assessed associations between known
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