Genome-wide association study identifies five susceptibility loci for glioma
作者： Sanjay Shete , Fay J Hosking , Lindsay B Robertson , Sara E Dobbins , Marc Sanson
DOI: 10.1038/NG.407
关键词: Genetic association 、 Genotyping 、 Genetics 、 Biology 、 Genome-wide association study 、 Linkage disequilibrium 、 Allele 、 Glioma 、 Single-nucleotide polymorphism 、 Locus (genetics)
摘要: To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in total 1,878 cases and 3,670 controls, with validation three additional independent series totaling 2,545 2,953 controls. We identified five loci glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; 2.34 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; 7.24 10(-15)), 20q13.33 (rs6010620, RTEL1; 2.52 10(-12)) 11q23.3 (rs498872, PHLDB1; 1.07 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the developing provide insight into disease causation this primary brain tumor.
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