Anatomic mapping of molecular subtypes in diffuse glioma.

摘要: Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according cell origin theory. However, anatomic distribution of unique subtypes not widely investigated. The relationship between phenotype and histological subgroup were also vague based on tumor location. Our group focuses the study distinctive subgroups histology subtypes, explores possibility their consistency clinical background. We retrospectively reviewed 143 cases with both information (IDH1/TERT/1p19q) MRI images diagnosed cerebral diffuse gliomas. analyzed its subtypes. influence location, stratification diagnosis survival outcome investigated well. Anatomic locations indicate varied outcome. Based that, it can be stratified into five principal IDH1/TERT/1p19q status. Triple-positive (IDH1 TERT mutation 1p19q codeletion) tended oligodendroglioma present much better compared only who is glioblastoma inclined (median overall 39 months VS 18 months). Five demonstrated locational distribution. This kind feature consistent corresponding Each has which indicates Molecular perfect complementary tool for precise diagnosis. Integration histomolecular will more helpful routine practice future.