Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy

作者: Stefan Blüml , Ashley S. Margol , Richard Sposto , Rebekah J. Kennedy , Nathan J. Robison

DOI: 10.1093/NEUONC/NOV097

关键词:

摘要: BACKGROUND: Medulloblastomas in children can be categorized into four molecular subgroups with differing clinical characteristics such that subgroup determination aids prognostication and risk-adaptive treatment strategies. Magnetic resonance spectroscopy (MRS) is a widely available, non-invasive tool used to determine metabolic of tumors providing diagnostic information without the need for tumor tissue. In this study we investigated hypothesis metabolite concentrations measured by MRS would differ between medulloblastoma allowing accurate determination. METHODS: was measure metabolites medulloblastomas across (SHH = 12, Groups 3/4 17, WNT 1). Levels fourteen were analyzed those which most discriminant order construct multivariable classifier distinguish combined Group SHH tumors. RESULTS: revealed distinct spectral features. A five inclusive creatine, myo-inositol, taurine, aspartate lipid 13a developed could discriminate excellent accuracy (cross-validated Area Under Curve AUC 0.88). 3 4 demonstrated profiles readily detectable lower levels lipids high creatine. showed prominent choline low creatine little or no evidence taurine. CONCLUSIONS: The data show different metabolically as using MRS. potentially useful subgroups.

参考文章(29)
Susan Beckwitt Turkel, Mark D. Krieger, Sharon O’Neil, Rima Jubran, C. Jane Tavaré, Symptoms before and after posterior fossa surgery in pediatric patients. Pediatric Neurosurgery. ,vol. 48, pp. 21- 25 ,(2012) , 10.1159/000337730
Paul Gibson, Yiai Tong, Giles Robinson, Margaret C. Thompson, D. Spencer Currle, Christopher Eden, Tanya A. Kranenburg, Twala Hogg, Helen Poppleton, Julie Martin, David Finkelstein, Stanley Pounds, Aaron Weiss, Zoltan Patay, Matthew Scoggins, Robert Ogg, Yanxin Pei, Zeng-Jie Yang, Sonja Brun, Youngsoo Lee, Frederique Zindy, Janet C. Lindsey, Makoto M. Taketo, Frederick A. Boop, Robert A. Sanford, Amar Gajjar, Steven C. Clifford, Martine F. Roussel, Peter J. McKinnon, David H. Gutmann, David W. Ellison, Robert Wechsler-Reya, Richard J. Gilbertson, Subtypes of medulloblastoma have distinct developmental origins Nature. ,vol. 468, pp. 1095- 1099 ,(2010) , 10.1038/NATURE09587
Paul A. Northcott, David J. H. Shih, Marc Remke, Yoon-Jae Cho, Marcel Kool, Cynthia Hawkins, Charles G. Eberhart, Adrian Dubuc, Toumy Guettouche, Yoslayma Cardentey, Eric Bouffet, Scott L. Pomeroy, Marco Marra, David Malkin, James T. Rutka, Andrey Korshunov, Stefan Pfister, Michael D. Taylor, Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples Acta Neuropathologica. ,vol. 123, pp. 615- 626 ,(2012) , 10.1007/S00401-011-0899-7
Mariia O. Yuneva, Teresa W.M. Fan, Thaddeus D. Allen, Richard M. Higashi, Dana V. Ferraris, Takashi Tsukamoto, José M. Matés, Francisco J. Alonso, Chunmei Wang, Youngho Seo, Xin Chen, J. Michael Bishop, The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type Cell Metabolism. ,vol. 15, pp. 157- 170 ,(2012) , 10.1016/J.CMET.2011.12.015
Ed C. Schwalbe, Janet C. Lindsey, Debbie Straughton, Twala L. Hogg, Michael Cole, Hisham Megahed, Sarra L. Ryan, Meryl E. Lusher, Michael D. Taylor, Richard J. Gilbertson, David W. Ellison, Simon Bailey, Steven C. Clifford, Rapid diagnosis of medulloblastoma molecular subgroups. Clinical Cancer Research. ,vol. 17, pp. 1883- 1894 ,(2011) , 10.1158/1078-0432.CCR-10-2210
D. W. Parsons, M. Li, X. Zhang, S. Jones, R. J. Leary, J. C.-H. Lin, S. M. Boca, H. Carter, J. Samayoa, C. Bettegowda, G. L. Gallia, G. I. Jallo, Z. A. Binder, Y. Nikolsky, J. Hartigan, D. R. Smith, D. S. Gerhard, D. W. Fults, S. VandenBerg, M. S. Berger, S. K. N. Marie, S. M. O. Shinjo, C. Clara, P. C. Phillips, J. E. Minturn, J. A. Biegel, A. R. Judkins, A. C. Resnick, P. B. Storm, T. Curran, Y. He, B. A. Rasheed, H. S. Friedman, S. T. Keir, R. McLendon, P. A. Northcott, M. D. Taylor, P. C. Burger, G. J. Riggins, R. Karchin, G. Parmigiani, D. D. Bigner, H. Yan, N. Papadopoulos, B. Vogelstein, K. W. Kinzler, V. E. Velculescu, The Genetic Landscape of the Childhood Cancer Medulloblastoma Science. ,vol. 331, pp. 435- 439 ,(2011) , 10.1126/SCIENCE.1198056
Torsten Pietsch, Rene Schmidt, Marc Remke, Andrey Korshunov, Volker Hovestadt, David T. W. Jones, Jörg Felsberg, Kerstin Kaulich, Tobias Goschzik, Marcel Kool, Paul A. Northcott, Katja von Hoff, André O. von Bueren, Carsten Friedrich, Martin Mynarek, Heyko Skladny, Gudrun Fleischhack, Michael D. Taylor, Friedrich Cremer, Peter Lichter, Andreas Faldum, Guido Reifenberger, Stefan Rutkowski, Stefan M. Pfister, Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort Acta Neuropathologica. ,vol. 128, pp. 137- 149 ,(2014) , 10.1007/S00401-014-1276-0
Monique M Cherrier, Paul R Borghesani, Amy L Shelton, Celestia S Higano, Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study BMC Cancer. ,vol. 10, pp. 1- 8 ,(2010) , 10.1186/1471-2407-10-1
U. M. Braga-Neto, E. R. Dougherty, Is cross-validation valid for small-sample microarray classification? Bioinformatics. ,vol. 20, pp. 374- 380 ,(2004) , 10.1093/BIOINFORMATICS/BTG419
Amar Gajjar, Murali Chintagumpala, David Ashley, Stewart Kellie, Larry E Kun, Thomas E Merchant, Shaio Woo, Greg Wheeler, Valerie Ahern, Matthew J Krasin, Maryam Fouladi, Alberto Broniscer, Robert Krance, Gregory A Hale, Clinton F Stewart, Robert Dauser, Robert A Sanford, Christine Fuller, Ching Lau, James M Boyett, Dana Wallace, Richard J Gilbertson, Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial Lancet Oncology. ,vol. 7, pp. 813- 820 ,(2006) , 10.1016/S1470-2045(06)70867-1