Spatiotemporal Evolution of the Primary Glioblastoma Genome
作者： Jinkuk Kim , In-Hee Lee , Hee Jin Cho , Chul-Kee Park , Yang-Soon Jung
DOI: 10.1016/J.CCELL.2015.07.013
关键词: Temozolomide 、 Regimen 、 Dacarbazine 、 Isocitrate dehydrogenase 、 Cancer research 、 Genomic Profile 、 Biology 、 Bioinformatics 、 Genome 、 Glioma 、 Somatic hypermutation
摘要: Tumor recurrence following treatment is the major cause of mortality for glioblastoma multiforme (GBM) patients. Thus, insights on evolutionary process at are critical improved patient care. Here, we describe our genomic analyses initial and recurrent tumor specimens from each 38 GBM A substantial divergence in landscape driver alterations was associated with distant appearance a tumor, suggesting that profile can mislead targeted therapies distally recurred tumor. In addition, contrast to IDH1-mutated gliomas, IDH1-wild-type primary GBMs rarely developed hypermutation temozolomide (TMZ) treatment, indicating low risk TMZ-induced these tumors under standard regimen.
core.ac.uk
sci-hub.se 参考文章(53)
Qingtang Lin, Krishnakumar Balasubramanian, Dominic Fan, Sun-Jin Kim, Lixia Guo, Hua Wang, Menashe Bar-Eli, Kenneth D. Aldape, Isaiah J. Fidler, Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels Neoplasia. ,vol. 12, pp. 748- 754 ,(2010) , 10.1593/NEO.10602
Yuchen Jiao, Patrick J. Killela, Zachary J. Reitman, B. Ahmed Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, Sergio Rosemberg, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie, Chetan Bettegowda, Nishant Agrawal, Eric Lipp, Christopher J. Pirozzi, Giselle Y. Lopez, Yiping He, Henry S. Friedman, Allan H. Friedman, Gregory J. Riggins, Matthias Holdhoff, Peter Burger, Roger E. McLendon, Darell D. Bigner, Bert Vogelstein, Alan K. Meeker, Kenneth W. Kinzler, Nickolas Papadopoulos, Luis A. Diaz, Hai Yan, Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget. ,vol. 3, pp. 709- 722 ,(2012) , 10.18632/ONCOTARGET.588
Xiaochong Wu, Paul A Northcott, Adrian Dubuc, Adam J Dupuy, David JH Shih, Hendrik Witt, Sidney Croul, Eric Bouffet, Daniel W Fults, Charles G Eberhart, Livia Garzia, Timothy Van Meter, David Zagzag, Nada Jabado, Jeremy Schwartzentruber, Jacek Majewski, Todd E Scheetz, Stefan M Pfister, Andrey Korshunov, Xiao-Nan Li, Stephen W Scherer, Yoon-Jae Cho, Keiko Akagi, Tobey J MacDonald, Jan Koster, Martin G McCabe, Aaron L Sarver, V Peter Collins, William A Weiss, David A Largaespada, Lara S Collier, Michael D Taylor, None, Clonal selection drives genetic divergence of metastatic medulloblastoma Nature. ,vol. 482, pp. 529- 533 ,(2012) , 10.1038/NATURE10825
Vishnu Anand Cuddapah, Stefanie Robel, Stacey Watkins, Harald Sontheimer, A neurocentric perspective on glioma invasion Nature Reviews Neuroscience. ,vol. 15, pp. 455- 465 ,(2014) , 10.1038/NRN3765
David A. Nathanson, Beatrice Gini, Jack Mottahedeh, Koppany Visnyei, Tomoyuki Koga, German Gomez, Ascia Eskin, Kiwook Hwang, Jun Wang, Kenta Masui, Andres Paucar, Huijun Yang, Minori Ohashi, Shaojun Zhu, Jill Wykosky, Rachel Reed, Stanley F. Nelson, Timothy F. Cloughesy, C. David James, P. Nagesh Rao, Harley I. Kornblum, James R. Heath, Webster K. Cavenee, Frank B. Furnari, Paul S. Mischel, Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. ,vol. 343, pp. 72- 76 ,(2014) , 10.1126/SCIENCE.1241328
Sevin Turcan, Daniel Rohle, Anuj Goenka, Logan A. Walsh, Fang Fang, Emrullah Yilmaz, Carl Campos, Armida W. M. Fabius, Chao Lu, Patrick S. Ward, Craig B. Thompson, Andrew Kaufman, Olga Guryanova, Ross Levine, Adriana Heguy, Agnes Viale, Luc G. T. Morris, Jason T. Huse, Ingo K. Mellinghoff, Timothy A. Chan, IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype Nature. ,vol. 483, pp. 479- 483 ,(2012) , 10.1038/NATURE10866
Matija Snuderl, Ladan Fazlollahi, Long P. Le, Mai Nitta, Boryana H. Zhelyazkova, Christian J. Davidson, Sara Akhavanfard, Daniel P. Cahill, Kenneth D. Aldape, Rebecca A. Betensky, David N. Louis, A. John Iafrate, Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma Cancer Cell. ,vol. 20, pp. 810- 817 ,(2011) , 10.1016/J.CCR.2011.11.005
E. C. Holland, Glioblastoma multiforme: The terminator Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 6242- 6244 ,(2000) , 10.1073/PNAS.97.12.6242
Michael S Lawrence, Petar Stojanov, Paz Polak, Gregory V Kryukov, Kristian Cibulskis, Andrey Sivachenko, Scott L Carter, Chip Stewart, Craig H Mermel, Steven A Roberts, Adam Kiezun, Peter S Hammerman, Aaron McKenna, Yotam Drier, Lihua Zou, Alex H Ramos, Trevor J Pugh, Nicolas Stransky, Elena Helman, Jaegil Kim, Carrie Sougnez, Lauren Ambrogio, Elizabeth Nickerson, Erica Shefler, Maria L Cortés, Daniel Auclair, Gordon Saksena, Douglas Voet, Michael Noble, Daniel DiCara, Pei Lin, Lee Lichtenstein, David I Heiman, Timothy Fennell, Marcin Imielinski, Bryan Hernandez, Eran Hodis, Sylvan Baca, Austin M Dulak, Jens Lohr, Dan-Avi Landau, Catherine J Wu, Jorge Melendez-Zajgla, Alfredo Hidalgo-Miranda, Amnon Koren, Steven A McCarroll, Jaume Mora, Ryan S Lee, Brian Crompton, Robert Onofrio, Melissa Parkin, Wendy Winckler, Kristin Ardlie, Stacey B Gabriel, Charles WM Roberts, Jaclyn A Biegel, Kimberly Stegmaier, Adam J Bass, Levi A Garraway, Matthew Meyerson, Todd R Golub, Dmitry A Gordenin, Shamil Sunyaev, Eric S Lander, Gad Getz, None, Mutational heterogeneity in cancer and the search for new cancer-associated genes Nature. ,vol. 499, pp. 214- 218 ,(2013) , 10.1038/NATURE12213
, Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature. ,vol. 455, pp. 1061- 1068 ,(2008) , 10.1038/NATURE07385