Head of the Class: OLIG2 and Glioblastoma Phenotype.
作者： Nalin Leelatian , Rebecca A. Ihrie
DOI: 10.1016/J.CCELL.2016.04.007
关键词:
摘要: Genomic mapping has driven the classification of glioblastoma into distinct molecular subclasses, but mechanisms that regulate tumor subclass phenotypes are only now emerging. In this issue Cancer Cell, Lu et al. describe a phenotypic switch from PDGFRA-enriched "proneural" to EGFR-enriched "classical" features in upon ablation Olig2.
sci-hub.se 参考文章(10)
Jinkuk Kim, In-Hee Lee, Hee Jin Cho, Chul-Kee Park, Yang-Soon Jung, Yanghee Kim, So Hee Nam, Byung Sup Kim, Mark D. Johnson, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Kyeung Min Joo, Yeup Yoon, Woong-Yang Park, Jeongwu Lee, Peter J. Park, Do-Hyun Nam, Spatiotemporal Evolution of the Primary Glioblastoma Genome Cancer Cell. ,vol. 28, pp. 318- 328 ,(2015) , 10.1016/J.CCELL.2015.07.013
Keith L. Ligon, Emmanuelle Huillard, Shwetal Mehta, Santosh Kesari, Hongye Liu, John A. Alberta, Robert M. Bachoo, Michael Kane, David N. Louis, Ronald A. DePinho, David J. Anderson, Charles D. Stiles, David H. Rowitch, Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. ,vol. 53, pp. 503- 517 ,(2007) , 10.1016/J.NEURON.2007.01.009
A. P. Patel, I. Tirosh, J. J. Trombetta, A. K. Shalek, S. M. Gillespie, H. Wakimoto, D. P. Cahill, B. V. Nahed, W. T. Curry, R. L. Martuza, D. N. Louis, O. Rozenblatt-Rosen, M. L. Suva, A. Regev, B. E. Bernstein, Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma Science. ,vol. 344, pp. 1396- 1401 ,(2014) , 10.1126/SCIENCE.1254257
J. Halliday, K. Helmy, S. S. Pattwell, K. L. Pitter, Q. LaPlant, T. Ozawa, E. C. Holland, In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 5248- 5253 ,(2014) , 10.1073/PNAS.1321014111
N. J. Szerlip, A. Pedraza, D. Chakravarty, M. Azim, J. McGuire, Y. Fang, T. Ozawa, E. C. Holland, J. T. Huse, S. Jhanwar, M. A. Leversha, T. Mikkelsen, C. W. Brennan, Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 3041- 3046 ,(2012) , 10.1073/PNAS.1114033109
Mona Meyer, Jüri Reimand, Xiaoyang Lan, Renee Head, Xueming Zhu, Michelle Kushida, Jane Bayani, Jessica C. Pressey, Anath C. Lionel, Ian D. Clarke, Michael Cusimano, Jeremy A. Squire, Stephen W. Scherer, Mark Bernstein, Melanie A. Woodin, Gary D. Bader, Peter B. Dirks, Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 112, pp. 851- 856 ,(2015) , 10.1073/PNAS.1320611111
Heidi S. Phillips, Samir Kharbanda, Ruihuan Chen, William F. Forrest, Robert H. Soriano, Thomas D. Wu, Anjan Misra, Janice M. Nigro, Howard Colman, Liliana Soroceanu, P. Mickey Williams, Zora Modrusan, Burt G. Feuerstein, Ken Aldape, Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis Cancer Cell. ,vol. 9, pp. 157- 173 ,(2006) , 10.1016/J.CCR.2006.02.019
Ingo K. Mellinghoff, Andrew B. Lassman, Patrick Y. Wen, Signal transduction inhibitors and antiangiogenic therapies for malignant glioma. Glia. ,vol. 59, pp. 1205- 1212 ,(2011) , 10.1002/GLIA.21137
Roel GW Verhaak, Katherine A Hoadley, Elizabeth Purdom, Victoria Wang, Yuan Qi, Matthew D Wilkerson, C Ryan Miller, Li Ding, Todd Golub, Jill P Mesirov, Gabriele Alexe, Michael Lawrence, Michael O'Kelly, Pablo Tamayo, Barbara A Weir, Stacey Gabriel, Wendy Winckler, Supriya Gupta, Lakshmi Jakkula, Heidi S Feiler, J Graeme Hodgson, C David James, Jann N Sarkaria, Cameron Brennan, Ari Kahn, Paul T Spellman, Richard K Wilson, Terence P Speed, Joe W Gray, Matthew Meyerson, Gad Getz, Charles M Perou, D Neil Hayes, None, Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell. ,vol. 17, pp. 98- 110 ,(2010) , 10.1016/J.CCR.2009.12.020
Fanghui Lu, Ying Chen, Chuntao Zhao, Haibo Wang, Danyang He, Lingli Xu, Jincheng Wang, Xuelian He, Yaqi Deng, Ellen E. Lu, Xue Liu, Ravinder Verma, Hong Bu, Rachid Drissi, Maryam Fouladi, Anat O. Stemmer-Rachamimov, Dennis Burns, Mei Xin, Joshua B. Rubin, El Mustapha Bahassi, Peter Canoll, Eric C. Holland, Q. Richard Lu, Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma Cancer Cell. ,vol. 29, pp. 669- 683 ,(2016) , 10.1016/J.CCELL.2016.03.027