Recurrent Glioblastomas Reveal Molecular Subtypes Associated with Mechanistic Implications of Drug-Resistance.

摘要: Previously, transcriptomic profiling studies have shown distinct molecular subtypes of glioblastomas. It has also been suggested that the recurrence glioblastomas could be achieved by reprograming tumors, however, their characteristics are not yet fully understood. Here, to gain mechanistic insights on phenotypes recurrent glioblastomas, gene expression was performed 43 cases including 15 paired primary and cases. Unsupervised clustering analyses revealed two G1 G2, which were characterized proliferation neuron-like traits, respectively. While tumors classified as subtype, showed types. Compared in subtype did show alteration. By contrast, G2 changes from type one. We observed stemness-related genes altered DNA-repair (i.e., AURK, HOX, MGMT, MSH6) might responsible for acquisition drug resistance mechanism during tumor a subtype-specific manner. suggest may choose different strategies escape chemotherapeutic treatment recurrence. Our results helpful determine personalized therapeutic strategy against heterogeneous glioma