The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors.
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DOI: 10.3390/IJMS19030879
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摘要: The fundamental function of ribonucleic acids is to transfer genetic information from DNA protein during translation process, however, this not the only way connecting active RNA sequences with essential biological processes. Up until now, many subclasses different size, structure, and were identified. Among them, there are non-coding single-stranded microRNAs (miRNAs). This subclass comprises RNAs 19–25 nucleotides in length that modulate activity well-defined coding play a crucial role physiological pathological miRNA genes located both exons, introns, also within non-translated regions. Several miRNAs transcribed adjacent called cluster. One largest ones miR-17-92 cluster known as OncomiR-1 due its strong link oncogenesis. Six have been shown important roles various cellular processes but through inhibition cell death cancer-relevant Due origin similarity sequence, paralogs, miR-106b-25 miR-106a-363 clusters defined. Here we discuss oncogenic those subgroups found types cancers, including brain tumors.
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