miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants
作者： T. Desvignes , P. Batzel , E. Berezikov , K. Eilbeck , J.T. Eppig
DOI: 10.1016/J.TIG.2015.09.002
关键词:
摘要: High-throughput sequencing of miRNAs has revealed the diversity and variability mature functional short noncoding RNAs, including their genomic origins, biogenesis pathways, sequence variability, newly identified products such as miRNA-offset RNAs (moRs). Here we review known cases alternative miRNA-like RNA fragments propose a revised definition to encompass this diversity. We then nomenclature guidelines for extend conventions align with those protein-coding genes established by international consortia. Finally, suggest system full complexity variations (i.e., isomiRs) in analysis small experiments.
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