The addition of Sunitinib to radiation delays tumor growth in a murine model of glioblastoma
作者： Randy D’Amico , Liang Lei , Benjamin C Kennedy , Julia Sisti , Victoria Ebiana
DOI: 10.1179/1743132812Y.0000000005
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摘要: AbstractObjectives: Recent preclinical studies suggest that treating glioblastoma (GBM) with a combination of targeted chemotherapy and radiotherapy may enhance the anti-tumor effects both therapies. However, these treatments on glioma growth progression are poorly understood.Methods: In this study, we have tested therapy in mouse model utilizes PDGF-IRES-Cre-expressing retrovirus to infect adult glial progenitors mice carrying conditional deletions Pten p53. This produces tumors histological features GBM 100% penetrance, making it powerful system test novel treatments. Sunitinib is an orally active, small molecule inhibitor multiple receptor tyrosine kinases critical for tumor angiogenesis, including PDGF receptors. We investigate addition radiotherapy, use bioluminescence imaging characterize treatment progression.Results: Tre...
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