Differentiation and definition of vascular-targeted therapies.

摘要: The therapeutic potential of targeting the tumor vascular supply is now widely recognized. Intense research and development activity has resulted in a variety investigational agents, number which are currently clinical development. As these novel agents quite distinct from cytotoxic drugs conventionally used treatment solid tumors, it will be particularly important to ensure early differentiation vascular-targeted therapies order encourage widespread understanding their benefits application clinic. Two groups have evolved: antiangiogenic vascular-disrupting approaches. These differ three key respects: physiologic target, type or extent disease that likely susceptible, scheduling. Inhibitors angiogenesis interfere with new vessel formation therefore preventative action, require chronic administration, particular benefit early-stage asymptomatic metastatic disease. Vascular-disrupting target established blood vessels, resulting ischemia necrosis. given acutely, show more immediate effects, may efficacy against advanced It essential can readily distinguished conventional an differences between two types fostered. Here, simple taxonomy nomenclature proposed anticipation this class realized as approaches advance settings anticancer strategy becomes available