ZD6474 Inhibits Vascular Endothelial Growth Factor Signaling, Angiogenesis, and Tumor Growth following Oral Administration
作者： Jane Kendrew , Laurent F Hennequin , Jon O Curwen , Donald J Ogilvie , Elaine S E Stokes
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摘要: Abstract ZD6474 [N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl) methoxy] quinazolin-4-amine] is a potent, po active, low molecular weight inhibitor of kinase insert domain-containing receptor [KDR/vascular endothelial growth factor receptor (VEGFR) 2] tyrosine kinase activity (IC50= 40 nm). This compound has some additional activity versus the tyrosine kinase activity of fms-like tyrosine kinase 4 (VEGFR3; IC50= 110 nm) and epidermal growth factor receptor (EGFR/HER1; IC50= 500 nm) and yet …
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