Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
作者： J. Baselga , D. Pfister , M.R. Cooper , R. Cohen , B. Burtness
DOI: 10.1200/JCO.2000.18.4.904
关键词:
摘要: PURPOSE: The epidermal growth factor (EGF) receptor is frequently overexpressed in epithelial tumors. C225 a human-to-murine chimeric monoclonal antibody that binds to the and inhibits of cancer cells expressing receptor. We evaluated pharmacokinetics toxicity patients with advanced tumors overexpressing EGF receptors. PATIENTS AND METHODS: treated 52 three successive phase I clinical trials as single dose (n = 13), weekly multiple 17), cisplatin 22). levels were 5, 20, 50, 100 mg/m2. In study combining cisplatin, limited either head neck or non–small-cell lung cancer, was further escalated 200 400 Cisplatin given at 60 mg/m2 once every 4 weeks, treatment continued for up 12 weeks if no disease progression occurred. RESULTS: displayed nonlinear pharmacokinetics, doses range 2...
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