The Physiology Of Transforming Growth Factor-α

摘要: Publisher Summary This chapter discusses the role of transforming growth factor- α (TGF- α) in proliferation normal cells and its potential importance tumor development. Research during past few years had made it evident that TGF- plays a physiology tissues. All types epithelial synthesize α. These have receptors, thus making them responsive to action an autocrine fashion. Even though there no direct proof vivo, is likely endogenous synthesis these epithelia drive their proliferation. The effect on substrate-dependent colony formation human keratinocytes has been studied detail. physiological ligand receptor cellular not only adult, but presumably even more importantly organ tissue Its tissues certainly does exclude establishment maintenance malignant character cells. contribute phenotypic transformation stimulates vivo. expression influences invasive behavior contributes induction neovascularization tumors malignancy-induced hypercalcemia.