Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis in Normal and Malignant Cells

摘要: The epidermal growth factor receptor (EGFR) is a tyrosine kinase whose physiological signaling activity regulates the morphogenesis and homeostasis of several tissues from worms to man. In contrast, aberrant caused by overexpression or mutational activation EGFR plays causal role in pathogenesis number human tumors. fidelity signals, which must be robust enough convey instructive cues cell while also preventing threat posed excess activity, guaranteed complex regulatory circuitry. A pervasive regulation played endocytosis. Owing its capacity instruct degradation activated EGFRs reduce expression at surface, endocytosis has been regarded historically as main cellular mechanism deputed attenuation signaling. More recently, great deal attention focused on understanding an element spatial activity. Herein, we discuss molecular mechanisms controlling endocytosis, they relate signal output implementation EGFR-driven biological programs. We will then focus reviewing variegated through escapes downregulation cancer cells. emerging picture assigns faulty concert with constitutive catalytic activation, prominent ominous oncogenic conversion EGFR.