Vascular Disrupting Action of Electrochemotherapy

摘要: Electrochemotherapy has besides a direct cytotoxic effect on tumor cells also vascular disrupting effect. Application of electric pulses to the induces transitory, but profound reduction in perfusion and oxygenation tumors. When bleomycin or cisplatin are present at time tissue electroporation, endothelial blood vessels affected, leading their apoptotic death. As consequence, flow treated is abrogated, extensive cell necrosis complete regression Therefore, electrochemotherapy can be beneficially used treatment bleeding metastases, as demonstrated several reported cases.