Vascular Meets of Localized Hyperthermia

摘要: When hyperthermia is applied in vitro, no fundamental differences can be seen between the response to normal and tumor cells. In vivo however, selective damage of cells achieved this phenomenon largely attributed a number characteristic properties blood vessels within solid tumors. Changes flow induced by influence heat either affecting delivery through changes dissipation or modulation microenvironment which may turn affect thermosensitivity Studies experimental human tumors suggest however that an accurate prediction during heating not possible so such cannot used as basis for combination with other therapy modalities. Even so, when underlying mechanisms responsible antitumor effects radiotherapy chemotherapy are considered, it becomes evident increase decrease could potentially contribute cytotoxic effect. A further interesting approach use antivascular drugs vascular-targeted photodynamic order specifically reduce prior treatment. Experimental data considerable enhancement effect approach. By reducing dissipation, future also overcoming problems related insufficient temperature increases frequently clinical setting.