Metabolic Status and Reaction to Heat of Normal and Tumor Tissue

摘要: The occurrence of differential heating and thermal sensitivity between malignant tumors normal tissues is thought to be due limited heat dissipation energy depletion in many solid which turn results from an inadequately functioning tumor microcirculation (Jain Ward-Hartley 1984; Song 1984, 1991; Vaupel Kallinowski 1987; Reinhold 1988; et al. 1988a; 1990). As a consequence the latter pathophysiological condition, supply drainage function are restricted or, at least, some areas, thus creating hostile metabolic microenvironment characterized by tissue hypoxia, acidosis, depletion. Thermal has been shown depend greatly on pH, nutritional status treated. Although no conclusive evidence so far available concerning ranking these pivotal factors, there doubt that rate homogeneity blood perfusion plays paramount role determining status.